ELISA PTPRB anti-
Quantity :50µL
Clone Number:
Aliases:HPTP BETA antibody; HPTPB antibody; Phosphacan receptor type B antibody; Protein tyrosine phosphatase receptor type B antibody; Protein-tyrosine phosphatase beta antibody; PTPB antibody; Ptprb antibody; PTPRB_ antibody; R PTP BETA antibody; R-PTP-beta antibody; Receptor-type tyrosine-protein phosphatase beta antibody; RPTPB antibody; VascµLar endothelial protein tyrosine phosphatase antibody; VE-PTP antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P23467
Immunogen:Recombinant Receptor-type tyrosine-protein phosphatase beta protein (1758-1997AA)
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Background:Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. RegµLates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regµLator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel Quantity during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen Affinity Purified
Conjµgate:Non-conjµgated
Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:PTPRB
Research Areas:Others