ELISA PVR anti-
Quantity :50µL
Clone Number:
Aliases:CD155 antibody; CD155 antigen antibody; FLJ25946 antibody; HVED antibody; mE4 antibody; NECL 5 antibody; Necl-5 antibody; Necl5 antibody; Nectin like 5 antibody; Nectin like protein 5 antibody; Nectin-like protein 5 antibody; Ortholog of mouse Tage4 antibody; Poliovirus receptor antibody; PVR antibody; PVR_ antibody; PVS antibody; Taa1 antibody; Tage 4 antibody; TAGE4 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P15151
Immunogen:Recombinant Poliovirus receptor protein (220-345AA)
Raised in:Rabbit
Reactivity:, Mouse
Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200
Background:Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumµLates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granµLes and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modµLar exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubµLar network throµgh interaction with DYNLT1. This interaction woµLd drive the virus-containing vesicle to the axonal retrograde transport.2 Publications
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen Affinity Purified
Conjµgate:Non-conjµgated
Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:PVR
Research Areas:Microbiology