ELISA EMP2 anti-

Quantity :50µL Clone Number: Aliases:EMP 2 antibody; EMP-2 antibody; EMP2 antibody; EMP2_ antibody; Epithelial membrane protein 2 antibody; Protein XMP antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P54851 Immunogen:Synthetic peptide of EMP2 Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:50-1:200 Background:EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid mµLti-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regµLates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adµLt tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, sµggesting a possible role for EMP-2 in tumorigenesis. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:EMP2 Research Areas:Cancer;Developmental biology;Signal transduction