ELISA ELAVL1 anti-

Quantity :50µg Clone Number: Aliases:ELAV (embryonic lethal abnormal vision Drosophila) like 1 antibody; ELAV (embryonic lethal; abnormal vision; Drosophila) like 1 (Hu antigen R) antibody; ELAV like 1 antibody; ELAV like RNA binding protein 1 antibody; ELAV-like protein 1 antibody; ELAV1 antibody; ELAV1_ antibody; Elavl1 antibody; Embryonic lethal abnormal vision drosophila homolog like 1 antibody; Hu Antigen R antibody; Hu-antigen R antibody; Hua antibody; HuR antibody; MelG antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15717 Immunogen:Recombinant ELAV-like protein 1 protein (2-326AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000 Background:RNA-binding protein that binds to the 3\\\'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3\\\'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5\\\'-UUUU[AG]UUU-3\\\' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3\\\'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regµLate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3\\\' UTR (PubMed:29180010). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ELAVL1 Research Areas:Epigenetics and Nuclear Signaling