ELISA PTTG1 anti-
Quantity :50µL
Clone Number:
Aliases:AW555095 antibody; C87862 antibody; Cut2 antibody; EAP 1 antibody; EAP1 antibody; ESP1 associated protein 1 antibody; Esp1-associated protein antibody; hPTTG antibody; MGC126883 antibody; MGC138276 antibody; Pds1 antibody; Pituitary tumor transforming 1 antibody; Pituitary tumor transforming protein 1 antibody; Pituitary tumor-transforming 1; isoform CRA_a antibody; Pituitary tumor-transforming 1; isoform CRA_b antibody; Pituitary tumor-transforming gene 1 antibody; Pituitary tumor-transforming gene 1 protein antibody; PTTG 1 antibody; PTTG antibody; PTTG1 antibody; PTTG1 protein antibody; PTTG1_ antibody; Pttg3 antibody; Securin antibody; Tumor transforming 1 antibody; Tumor transforming protein 1 antibody; Tumor-transforming protein 1 antibody; TUTR 1 antibody; TUTR1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:O95997
Immunogen:Synthetic peptide of PTTG1
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA, IHC; ELISA:1:2000-1:10000, IHC:1:100-1:300
Background:The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimµLation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, althoµgh it partially localizes in the nucleus.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen affinity purification
Conjµgate:Non-conjµgated
Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:PTTG1
Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology