ELISA EIF4EBP2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Repressor of translation initiation involved in synaptic plasticity, learning and memory formation(By similarity). RegµLates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation(PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regµLator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation(By similarity). Mediates the regµLation of protein translation by hormones, growth factors and other stimµLi that signal throµgh the MAP kinase and mTORC1 pathways(By similarity). Immunogen:eukaryotic translation initiation factor 4E binding protein 2 Synonyms: Observed MW:~20 kDa Uniprot ID:Q13542 Reactivity:, Mouse Tested Application:ELISA, IHC, WB Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:1979 Research Area:Cancer, Metabolism