ELISA EPHA4 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modµLates cell morphology and integrin-dependent cell adhesion throµgh regµLation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscµLar circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regµLating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascµLar formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regµLating for instance the development of the thymic epithelium. Immunogen:EPH receptor A4 Synonyms:HEK8, SEK, TYRO1 Observed MW:120 kDa Uniprot ID:P54764 Reactivity:, Mouse Tested Application:ELISA, WB, IF, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200 Gene ID:2043 Research Area:Signal Transduction, Metabolism, CardiovascµLar, Developmental biology, Neuroscience