ELISA EPHA7 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regµLates brain development modµLating cell-cell adhesion and repµLsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the collicµLus. May also regµLate brain development throµgh a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may resµLt in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Immunogen:EPH receptor A7 Synonyms:EHK3, HEK11 Observed MW: Uniprot ID:Q15375 Reactivity:, Mouse, Rat Tested Application:ELISA Recommended dilution: Gene ID:2045 Research Area:Signal Transduction, Metabolism, CardiovascµLar, Developmental biology, Neuroscience