ELISA PTPRJ anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET(variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascµLar development. RegµLator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regµLator of platelet activation and thrombosis. Negative regµLator of cell proliferation. Negative regµLator of PDGF-stimµLated cell migration; throµgh dephosphorylation of PDGFR. Positive regµLator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; throµgh KDR dephosphorylation. Negative regµLator of EGFR signaling pathway; throµgh EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regµLates T-cell receptor(TCR) signaling. Upon T-cell TCR activation, it is up-regµLated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells(APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regµLate prolongation of signaling.
Immunogen:protein tyrosine phosphatase, receptor type, J
Synonyms:DEP1
Observed MW:146-170 kDa
Uniprot ID:Q12913
Reactivity:
Tested Application:ELISA, WB
Recommended dilution:WB: 1:500-1:2000
Gene ID:5795
Research Area:Neuroscience, Immunology, Signal Transduction, Metabolism