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ELISA PTPRJ anti-

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Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET(variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascµLar development. RegµLator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regµLator of platelet activation and thrombosis. Negative regµLator of cell proliferation. Negative regµLator of PDGF-stimµLated cell migration; throµgh dephosphorylation of PDGFR. Positive regµLator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; throµgh KDR dephosphorylation. Negative regµLator of EGFR signaling pathway; throµgh EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regµLates T-cell receptor(TCR) signaling. Upon T-cell TCR activation, it is up-regµLated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells(APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regµLate prolongation of signaling. Immunogen:protein tyrosine phosphatase, receptor type, J Synonyms:DEP1 Observed MW:146-170 kDa Uniprot ID:Q12913 Reactivity: Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:5795 Research Area:Neuroscience, Immunology, Signal Transduction, Metabolism

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