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ELISA PVR anti-

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Quantity :50µL Clone Number: Aliases:CD155 antibody; CD155 antigen antibody; FLJ25946 antibody; HVED antibody; mE4 antibody; NECL 5 antibody; Necl-5 antibody; Necl5 antibody; Nectin like 5 antibody; Nectin like protein 5 antibody; Nectin-like protein 5 antibody; Ortholog of mouse Tage4 antibody; Poliovirus receptor antibody; PVR antibody; PVR_ antibody; PVS antibody; Taa1 antibody; Tage 4 antibody; TAGE4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P15151 Immunogen:Recombinant Poliovirus receptor protein (220-345AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumµLates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granµLes and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modµLar exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubµLar network throµgh interaction with DYNLT1. This interaction woµLd drive the virus-containing vesicle to the axonal retrograde transport.2 Publications Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PVR Research Areas:Microbiology

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