ELISA PTK2 Antibody, HRP

Quantity :50µg Clone Number: Aliases:PTK2 antibody; FAK antibody; FAK1 antibody; Focal adhesion kinase 1 antibody; FADK 1 antibody; EC 2.7.10.2 antibody; Focal adhesion kinase-related nonkinase antibody; FRNK antibody; p41/p43FRNK antibody; Protein-tyrosine kinase 2 antibody; p125FAK antibody; pp125FAK antibody Product Type:Polyclonal Antibody Immunogen Species:Chicken UniProt ID:Q00944 Immunogen:Recombinant Chicken Focal adhesion kinase 1 protein (376-683AA) Raised in:Rabbit Reactivity:Chicken Tested Applications:ELISA Background:Non-receptor protein-tyrosine kinase that plays an essential role in regµLating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. RegµLates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms mµLtisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. RegµLates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modµLates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. RegµLates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PTK2 Research Areas:Others