ELISA Phospho-AIRE (Ser156) anti-

Quantity :100µL Clone Number: Aliases:AIRE antibody; AIRE_ antibody; AIRE1 antibody; APECED antibody; APECED protein antibody; APS1 antibody; APSI antibody; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody; Autoimmune regµLator antibody; Autoimmune regµLator protein antibody; PGA1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43918 Immunogen:Peptide sequence around phosphorylation site of Serine156 P-G-S(p)-Q-L) derived from AIRE. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:1000 Background: The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs sµggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 throµgh 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 throµgh 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. Nagamine K., Nat. Genet. 17:393-398(1997). Aaltonen J., Nat. Genet. 17:399-403(1997). Hattori M., Nature 405:311-319(2000). Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AIRE Research Areas:Epigenetics and Nuclear Signaling;Immunology