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ELISA PTK2B (Ab-402) anti-

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Quantity :100µL Clone Number: Aliases:CADTK antibody; CAK-beta antibody; CAKB antibody; CAKbeta antibody; Calcium regµLated non receptor proline rich tyrosine kinase antibody; Calcium-dependent tyrosine kinase antibody; Cell adhesion kinase beta antibody; E430023O05Rik antibody; EC 2.7.10.2 antibody; FADK 2 antibody; FADK2 antibody; FAK2 antibody; FAK2_ antibody; Focal adhesion kinase 2 antibody; MGC124628 antibody; PKB antibody; Proline-rich tyrosine kinase 2 antibody; Protein kinase B antibody; Protein Tyrosine Kinase 2 Beta antibody; Protein-tyrosine kinase 2-beta antibody; PTK antibody; PTK2B antibody; PTK2B protein tyrosine kinase 2 beta antibody; PYK2 antibody; RAFTK antibody; RAFTK2 antibody; Related adhesion focal tyrosine kinase antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q14289 Immunogen:Peptide sequence around aa.400~404 (D-I-Y-A-E) derived from Pyk2. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 Background:Involved in calcium induced regµLation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regµLate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimµLation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation. Gluck SL, et al. (2004) J Clin Invest; 114(12): 1696-1699 Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98(17): 9784-9789 Tian D, et al. (2002) Mol Cell Biol; 22(8): 2650-2662 Lu Z, et al. (2001) Mol Cell Biol; 21(12): 4016-4031 Krishnan HH, et al. (2006) J Virol; 80(3): 1167-1180 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PTK2B Research Areas:Cancer;Metabolism;Signal transduction

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