ELISA Phospho-ABL1|ABL2 (Tyr393|439) anti-
Quantity :100µL
Clone Number:
Aliases:Abelson murine leukemia viral oncogene homolog 1; c-ABL; p150
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P00519/P42684
Immunogen:Peptide sequence around phosphorylation site of tyrosine 393/439 (D-T-Y(p)-T-A) derived from ABL1/2.
Raised in:Rabbit
Reactivity:, Mouse
Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200
Background:
RegµLates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. RegµLates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650.
Danial, N.N. et al. (2000) Oncogene 19, 2523-2531.
Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637.
Pluk, H. et al. (2002) Cell 108, 247-259.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Conjµgate:Non-conjµgated
Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:ABL1/ABL2
Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction