ELISA RBL2 Antibody, Biotin

Quantity :50µL Clone Number: Aliases:130 kDa retinoblastoma associated protein antibody; 130 kDa retinoblastoma-associated protein antibody; IB4 antibody; p130 antibody; PPAR-alpha-interacting complex protein 128 antibody; PRB2 antibody; Rb2 antibody; Rbl2 antibody; RBL2_ antibody; RBR 2 antibody; RBR-2 antibody; RBR2 antibody; Retinoblastoma like 2 antibody; Retinoblastoma-like protein 2 antibody; Retinoblastoma-related protein 2 antibody; RIC128 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q08999 Immunogen:Recombinant Retinoblastoma-like protein 2 protein (417-616AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Key regµLator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particµLar, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RBL2 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology