Skip to Content

ELISA PUM2 anti-

https://www.ids-kits.com/web/image/product.template/102112/image_1920?unique=1dd0f6a
Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element(PRE), 5'-µgUANAUA-3', that is related to the Nanos Response Element(NRE)(, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation(PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs(PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regµLation(PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection(PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regµLated by the lncRNA NORAD(non-coding RNA activated by DNA damage) which, due to its high abundance and mµLtitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm(PubMed:26724866). May regµLate DCUN1D3 mRNA levels(PubMed:25349211). May support proliferation and self-renewal of stem cells. Immunogen:pumilio homolog 2(Drosophila) Synonyms:KIAA0235, PUMH2 Observed MW:140 kDa Uniprot ID:Q8TB72 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:23369 Research Area:Stem Cells, Immunology, Metabolism

470.00 € 470.0 EUR 470.00 €

470.00 €

Not Available For Sale

This combination does not exist.

Terms and Conditions
30-day money-back guarantee
Shipping: 2-3 Business Days